The mechanical and biological properties of a novel biodegradable polycaprolactone -magnesium porous scaffold for bone tissue engineering 1Wong KHM 1 YeungKWK 2ChuPK 1Luk KDK +1Cheung KMC +1Department of Orthopaedics and Traumatology The University of Hong Kong Pokfulam Hong Kong China 2Department of Physics and Materials Science City University of Hong PARSIPPANY N J Feb 6 2020 /PRNewswire/ — Onkos Surgical is pleased to announce the launch of GenVie™ Magnesium Bone Scaffold a novel biologic technology that further expands Onkos' reach in complex limb salvage procedures GenVie is the first 510(k) cleared magnesium-based bone void filler in the orthopaedic marketplace and is available via a private label distribution agreement

Bioresorbable stent

Magnesium-based scaffolds have been approved for use in several countries around the world The only commercially available magnesium-based scaffold consists of a magnesium alloy approximately 95% of which resorbs within one year of implantation Thousands of commercially available magnesium-based scaffolds have been implanted Promising

Magnesium- (Mg-) based and iron- (Fe-) based metals have been used which include Mg-RE (rare earth elements) [29–33] Mg-Ca- [34 35] pure Fe [36 37] Fe-Mn alloys [38 39] and Fe foam for bone replacement scaffold Mg and its alloys have been proposed for orthopaedic implants due to their supportive physical properties to human bones

In this study a nanobiocomposite scaffold was fabricated by combining sodium alginate polyvinyl alcohol silk fibroin and magnesium hydroxide nanorods The structural characteristics and properties of the scaffold were identified by field emission scanning electron microscope (FE-SEM) thermogravi

Magnesium (Mg) as a biodegradable metal with properly mechanical properties has been investigating for a long history In this study Mg powder poly (lactide-co-glycolide) (PLGA) β-tricalcium phosphate (β-TCP) were the elements to formulate a novel porous PLGA/TCP/Mg (PTM) scaffolds using low temperature rapid prototyping (LT-RP) technology

Preclinical Evaluation of a Novel Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold in Porcine Coronary Artery at 6 Months Jian-Feng Zheng MSC aHong Qiu MD Yuan Tian BS b Xiao-Ying Hu MD a Tong Luo MD Chao Wu MD Yi Tian MD cYue Tang MD Lai-Feng Song MD dLi Li MD Liang Xu MD a Bo Xu MBBS a Run-Lin Gao MDa ABSTRACT

A novel open

Apr 01 2016The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties In this work two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH)

Jun 01 2019In this regard Cheng et al showed that MG-63 cells were well grown and proliferate in open-porous magnesium scaffold Furthermore Kim et al presented scaffolds containing hydroxyapatite and Gel that could improve cell attachment of MG-63 cells However there is no research on fabricating FHA-Mg-Gel scaffolds and according to advantages

(5) A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Scientific reports January 1 2016 Meng-Qi Cheng Tuerhongjiang Wahafu Guo-Feng Jiang Wei Liu Yu-Qin Qiao Xiao-Chun Peng Tao Cheng Xian-Long Zhang Guo He Xuan-Yong Liu

Nov 01 20181 Introduction Bone tissue engineering scaffolds provide a promising strategy to the regeneration of segmental bone defects [] To achieve good therapeutic effect the scaffold should have an open porous structure for tissue ingrowth and the exchange of nutrients and oxygen [] To allow a complete replacement by the regenerated host tissue the scaffold should be degradable without

Feb 06 2020PARSIPPANY N J Feb 6 2020 /PRNewswire/ -- Onkos Surgical is pleased to announce the launch of GenVie™ Magnesium Bone Scaffold a novel biologic technology that further expands Onkos' reach in complex limb salvage procedures GenVie is the first 510(k) cleared magnesium-based bone void filler in the orthopaedic marketplace and is available via a private label

Mar 28 2018Cheng M Q Wahafu1 T Jiang G f Liu W Qiao Y Q Peng X C Cheng T Zhang X L He G and Liu X Y 2016 A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Sci Rep 6 1–14

(5) A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Scientific reports January 1 2016 Meng-Qi Cheng Tuerhongjiang Wahafu Guo-Feng Jiang Wei Liu Yu-Qin Qiao Xiao-Chun Peng Tao Cheng Xian-Long Zhang Guo He Xuan-Yong Liu

This study employs a computational approach to analyse the impact of morphological changes on the structural properties of biodegradable porous Mg subjected to a dynamic immersion test for its application as a bone scaffold Porous Mg was immersed in a dynamic immersion test for 24 48 and 72 h Twelve specimens were prepared and scanned using micro-CT and then reconstructed into a 3D model

The improvement of corrosion resistance biocompatibility

A magnesium scaffold is a promising biodegradable bone repair material However its poor corrosion resistance limits its clinical application In this study we improved the corrosion resistance biocompatibility and osteointergration ability of magnesium by alloying it with neodymium (Nd) and zinc (Zn) then fabricated a novel open-porous Mg

Meng-qi Cheng Tuerhongjiang Wahafu Guo-feng Jiang Wei Liu Yu-qin Qiao Xiao-chun Peng Tao Cheng Xian-long Zhang Guo He Xuan-yong Liu A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration

A magnesium scaffold is a promising biodegradable bone repair material However its poor corrosion resistance limits its clinical application In this study we improved the corrosion resistance biocompatibility and osteointergration ability of magnesium by alloying it with neodymium (Nd) and zinc (Zn) then fabricated a novel open-porous Mg

Jun 01 2019However fabrication of an open cell Mg-based scaffold with high porosity pore interconnectivity and significant strength is a challenging task due to the highly reactive nature of magnesium (Song 2007 Wang and Xiong 2013 Arifvianto and Zhou 2014) in a body fluid Several methods have been reported for producing Mg-based porous structures

Jan 01 2005A three dimensional interconnected matrix of high porosity may be used as a scaffold for seeding cells for tissue reconstruction repair or remodeling This paper comprises a novel method for preparation of porous alginate scaffolds for tissue engineering of liver cartilage bone etc

One of the methods is using Fe as a scaffold material as Fe has also shown biodegradation properties 45 46 Contrary to magnesium the main issue with Fe porous structures is their too slow degradation rate 4 47 One of the promising methods to decrease the degradation rate of magnesium down to the tissue healing speed is using coating or

Introduction: Biodegradable metals made of magnesium and its alloys have been investigated as implant materials for more than 100 years [1] But just recently first in vivo results confirmed the suitability of open-porous biodegradable scaffolds made from sintered magnesium fibers providing a stochstic distribution of pores [2] In this